HCG (Human Chorionic Gonadotropin / Pregnyl) — Human Chorionic Gonadotropin (HCG) is an FDA-approved hormone medication with established clinical applications in men’s hormonal health. Structurally similar to luteinizing hormone (LH), HCG signals the testes to produce testosterone naturally, making it a valuable tool both as a standalone therapy and as an adjunct to testosterone replacement therapy (TRT).
For men on TRT, HCG is commonly prescribed to prevent testicular atrophy and preserve fertility — two of the most significant concerns associated with long-term exogenous testosterone use. For men not yet on TRT, HCG may be used to stimulate the body’s own testosterone production, offering a more natural hormonal pathway.
Clinical Applications
- Maintaining testicular size and function during TRT
- Supporting natural testosterone production
- Preserving fertility in men of reproductive age
- Secondary hypogonadism management
How It Works HCG mimics LH, the hormone responsible for signaling Leydig cells in the testes to produce testosterone and maintain sperm production. By keeping this signaling pathway active, HCG helps prevent the suppression of natural testosterone production that typically accompanies exogenous hormone therapy.
Prescription required. Individual results vary.
